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Abdominal Obesity-Related Disturbance of Insulin Sensitivity Is Associated with CD8+ EMRA Cells in the Elderly

verfasst von
Tim K. Boßlau, Paulina Wasserfurth, Britta Krüger, Thomas Reichel, Jana Palmowski, Josefine Nebl, Christopher Weyh, Alexander Schenk, Niklas Joisten, Frank Stahl, Stefanie Thoms, Kristina Gebhardt, Andreas Hahn, Karsten Krüger
Abstract

Aging and overweight increase the risk of developing type 2 diabetes mellitus. In this cross-sectional study, we aimed to investigate the potential mediating role of T-EMRA cells and inflammatory markers in the development of a decreased insulin sensitivity. A total of 134 healthy older volunteers were recruited (age 59.2 (SD 5.6) years). T cell subpopulations were analyzed by flow cytometry. Furthermore, body composition, HOMA-IR, plasma tryptophan (Trp) metabolites, as well as cytokines and adipokines were determined. Using subgroup and covariance analyses, the influence of BMI on the parameters was evaluated. Moreover, correlation, multiple regression, and mediation analyses were performed. In the subgroup of participants with obesity, an increased proportion of CD8+EMRA cells and elevated concentrations of plasma kynurenine (KYN) were found compared to the lower-weight subgroups. Linear regression analysis revealed that an elevated HOMA-IR could be predicted by a higher proportion of CD8+EMRA cells and KYN levels. A mediation analysis showed a robust indirect effect of the Waist-to-hip ratio on HOMA-IR mediated by CD8+EMRA cells. Thus, the deleterious effects of abdominal obesity on glucose metabolism might be mediated by CD8+EMRA cells in the elderly. Longitudinal studies should validate this assumption and analyze the suitability of CD8+EMRA cells as early predictors of incipient prediabetes.

Organisationseinheit(en)
Institut für Lebensmittelwissenschaft und Humanernährung
Institut für Technische Chemie
Abteilung Ernährungsphysiologie und Humanernährung
Externe Organisation(en)
Justus-Liebig-Universität Gießen
Technische Universität Dortmund
Typ
Artikel
Journal
Cells
Band
10
ISSN
2073-4409
Publikationsdatum
23.04.2021
Publikationsstatus
Veröffentlicht
Peer-reviewed
Ja
ASJC Scopus Sachgebiete
Medizin (insg.)
Ziele für nachhaltige Entwicklung
SDG 3 – Gute Gesundheit und Wohlergehen
Elektronische Version(en)
https://doi.org/10.3390/cells10050998 (Zugang: Offen)