Impact of nutrition on short-term exercise-induced sirtuin regulation

Vegans differ from omnivores and LACTO-OVO vegetarians

authored by

Arne Björn Potthast, Josefine Nebl, Paulina Wasserfurth, S. Haufe, J. Eigendorf, Andreas Hahn, Anibh Das

Abstract

Both nutrition and exercise are known to affect metabolic regulation in humans. Sirtuins are essential regulators of cellular energy metabolism; SIRT1, SIRT3, and SIRT4 have a direct effect on glycolysis, oxidative phosphorylation, and fatty acid oxidation. This cross-sectional study investigates the effect of different diets on exercise-induced regulation of sirtuins. SIRT1 and SIRT3– SIRT5 were measured in blood from omnivorous, lacto-ovo vegetarian, and vegan recreational runners (21–25 subjects, respectively) before and after exercise at the transcript, protein, and enzymatic levels. SIRT1, SIRT3, and SIRT5 enzyme activities increased during exercise in omnivores and lacto-ovo vegetarians, commensurate with increased energy demand. However, activities decreased in vegans. Malondialdehyde as a surrogate marker of oxidative stress inversely correlated with sirtuin activities and was elevated in vegans after exercise compared to both other groups. A significant negative correlation of all sirtuins with the intake of the antioxidative substances, ascorbate and tocopherol, was found. In vegan participants, increased oxidative stress despite higher amounts of the antioxidative substances in the diet was observed after exercise.

Organisation(s)

Nutrition Physiology and Human Nutrition Section
Institute of Food Science and Human Nutrition
Institute of Sports Science

External Organisation(s)

Hannover Medical School (MHH)

Type

Article

Journal

NUTRIENTS

Volume

12

ISSN

2072-6643

Publication date

05.04.2020

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Food Science, Nutrition and Dietetics

Electronic version(s)

https://doi.org/10.3390/nu12041004 (Access: Open)