Effect of two different multimicronutrient supplements on vitamin D status in women of childbearing age: a randomized trial

authored by
S. Pilz, Andreas Hahn, C. Schön, M. Wilhelm, R. Obeid
Abstract

The German Nutrition Society raised in 2012 the recommended daily vitamin D intake from 200 to 800 international units (IU) to achieve 25-hydroxyvitamin D (25 (OH) D) levels of at least 50 nmol/L, even when endogenous vitamin D synthesis is minimal such as in winter. We aimed to evaluate this recommendation in women of childbearing age. This is a single-center, randomized, open trial conducted from 8 January to 9 May 2016 in Esslingen, Germany. We randomized 201 apparently healthy women to receive for 8 weeks a daily multimicronutrient supplement containing either 200 IU (n = 100) or 800 IU vitamin D3 (n = 101). Primary outcome measure was serum 25 (OH) D. 196 participants completed the trial. Increases in 25 (OH) D (median with interquartile range) from baseline to study end were 13.2 (5.9 to 20.7) nmol/L in the 200 IU group, and 35.8 (18.2 to 52.8) nmol/L in the 800 IU group (p < 0.001 for the between group difference). At study end, levels of ≥50 nmol/L were present in 70.4% of the 200 IU group and in 99% of the 800 IU group. Participants on hormonal contraceptives had higher baseline levels and a stronger increase in 25 (OH) D. In conclusion, daily supplementation of 800 IU vitamin D3 during wintertime in Germany is sufficient to achieve a 25 (OH) D level of at least 50 nmol/L in almost all women of childbearing age, whereas 200 IU are insufficient.

Organisation(s)
Institute of Food Science and Human Nutrition
Nutrition Physiology and Human Nutrition Section
External Organisation(s)
Medical University of Graz
BioTeSys GmbH Esslingen
Ulm University of Applied Sciences
Aarhus University
Type
Article
Journal
NUTRIENTS
Volume
9
ISSN
2072-6643
Publication date
04.01.2017
Publication status
Published
Peer reviewed
Yes
ASJC Scopus subject areas
Food Science, Nutrition and Dietetics
Electronic version(s)
https://doi.org/10.3390/nu9010030 (Access: Open)