Effect of two different multimicronutrient supplements on vitamin D status in women of childbearing age: a randomized trial

verfasst von

S. Pilz, Andreas Hahn, C. Schön, M. Wilhelm, R. Obeid

Abstract

The German Nutrition Society raised in 2012 the recommended daily vitamin D intake from 200 to 800 international units (IU) to achieve 25-hydroxyvitamin D (25 (OH) D) levels of at least 50 nmol/L, even when endogenous vitamin D synthesis is minimal such as in winter. We aimed to evaluate this recommendation in women of childbearing age. This is a single-center, randomized, open trial conducted from 8 January to 9 May 2016 in Esslingen, Germany. We randomized 201 apparently healthy women to receive for 8 weeks a daily multimicronutrient supplement containing either 200 IU (n = 100) or 800 IU vitamin D3 (n = 101). Primary outcome measure was serum 25 (OH) D. 196 participants completed the trial. Increases in 25 (OH) D (median with interquartile range) from baseline to study end were 13.2 (5.9 to 20.7) nmol/L in the 200 IU group, and 35.8 (18.2 to 52.8) nmol/L in the 800 IU group (p < 0.001 for the between group difference). At study end, levels of ≥50 nmol/L were present in 70.4% of the 200 IU group and in 99% of the 800 IU group. Participants on hormonal contraceptives had higher baseline levels and a stronger increase in 25 (OH) D. In conclusion, daily supplementation of 800 IU vitamin D3 during wintertime in Germany is sufficient to achieve a 25 (OH) D level of at least 50 nmol/L in almost all women of childbearing age, whereas 200 IU are insufficient.

Organisationseinheit(en)

Institut für Lebensmittelwissenschaft und Humanernährung
Abteilung Ernährungsphysiologie und Humanernährung

Externe Organisation(en)

Medical University of Graz
BioTeSys GmbH Esslingen
Technische Hochschule Ulm
Aarhus University

Typ

Artikel

Journal

NUTRIENTS

Band

9

ISSN

2072-6643

Publikationsdatum

04.01.2017

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Lebensmittelwissenschaften, Ernährung und Diätetik

Elektronische Version(en)

https://doi.org/10.3390/nu9010030 (Zugang: Offen)